Recently, Wake Forest University Baptist Medical Center and the University of Heilderberg have discovered a gene that contributes to the occurrence of chronic kidney disease (CKD) in diabetic patients. Diabetes has been known As with the biggest cause of chronic kidney disease.
One of the initiators of the dr.Fredman say that it has been 20 years this has been done the search for genes that play a role in diabetic nephropathy.
The gene was named carnosinase 1 which is located on chromosome 8. Carnosinase gene produces an enzyme called carnosinase; carnosinase contains 5 leucine/5leucine and called CNDP1 Manheim. This Carnosinase break down and inactivate the protective effects of carnosine. Carnosine is an enzyme that plays has a protective effect on renal tissue damage and as a destroyer of free radicals.
A study of 242 European white people found that those who had low levels of carnosinase were more protected against the incidence of diabetic nephropathy.
Based on the above, the potential for therapy and new markers for diabetic nephropathy is currently possible. Carnosinase inhibitors are currently being tested in Germany. While this is still evaluated whether the administration should carnosine or carnosinase inhibitor that will protect the progression of diabetic nephropathy.
One of the initiators of the dr.Fredman say that it has been 20 years this has been done the search for genes that play a role in diabetic nephropathy.
The gene was named carnosinase 1 which is located on chromosome 8. Carnosinase gene produces an enzyme called carnosinase; carnosinase contains 5 leucine/5leucine and called CNDP1 Manheim. This Carnosinase break down and inactivate the protective effects of carnosine. Carnosine is an enzyme that plays has a protective effect on renal tissue damage and as a destroyer of free radicals.
A study of 242 European white people found that those who had low levels of carnosinase were more protected against the incidence of diabetic nephropathy.
Based on the above, the potential for therapy and new markers for diabetic nephropathy is currently possible. Carnosinase inhibitors are currently being tested in Germany. While this is still evaluated whether the administration should carnosine or carnosinase inhibitor that will protect the progression of diabetic nephropathy.
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